Research Interests Oxidative DNA Damage and DNA RepairWe are examining the repair of synthetic ionizing radiation DNA damage in bacteria and mammalian cells. Understanding the mechanism of repair of these lesions may aid in designing new radiotherapy protocols or additional treatments with radiation to enhance treatment. SenescenceWe are investigating the role of oxidative DNA damage in the senescent process. Senescence is an in vitro model of aging.
Specialized Techniques/Procedures Mammalian Cell Culture Introduction of plasmid DNA into mammalian cells Real Time PCR Isolation of RNA The generation of recombinant plasmids Sequencing Southern analysis