Research Interests Role of ERK activation in acid - base metabolic responses. Glitazones, cellular acidosis and acute MAPkinase activation related to cancer cell proliferation Role of cell pH in cellular proliferation and apoptosis. Acute vs sustained ERK activation in cellular responses and glutamine metabolism. Role of glutamate and glutamine transporters in regulating glutamine metabolism. Glucocorticoid and IGF-1 modulation of glutamate/NHE transporter activities. Glutamine, growth hormone and IGF-1 in catabolic illnesses in relation to acid-base balance and anabolic responses. Glitazones and glutamine metabolism related to extracellular matrix formation in diabetes mellitus. Cell pH and caspase 3 activity in regulating acid extrusion in renal and solid tumors.