Course Offerings
Advances in Gene Therapy
(2 hours of credit)
Ronald Klein, Ph.D., Course Director
Text: Understanding Gene Therapy
Nicholas R. Lemoine
(Editor)
Schedule – TBA
Location – TBA
1hr/lecture
| Lecture Number |
Lecturer |
Topic |
| 1, 2 |
Klein |
History of gene therapy and related clinical trials |
| 3, 4 |
Klein |
Nonviral and viral vectors |
| 5, 6 |
Ryman |
RNA viruses |
| 7, 8 |
Mathis |
Adenovirus vectors |
| 9, 10 |
Klein |
Adeno-associated virus vectors |
| 11, 12 |
Turturro |
Vector targeting |
| 3 hr |
Klein |
Student oral presentations |
| 2 hr |
Mid-term Exam |
|
| 13, 14 |
Williams |
Blocking gene expression |
| 15, 16 |
Zhang |
Immune responses to vectors and transgene products |
| 17, 18 |
Duan |
Cell-based therapies |
| 19, 20 |
Turturro |
Single gene and multifactorial disorders |
| 20, 21 |
Williams |
Cancer gene therapy |
| 21, 22 |
Klein |
CNS gene therapy |
| 23, 24 |
Mathis |
Gene therapy bioethics |
| 3 hr |
Klein |
Student oral presentations |
| 2 hr |
Final Exam |
Catalog description: An overview of gene therapy emphasizing the clinical history, the types of diseases that could benefit the most, and ethical issues. Some of the major gene transfer vector systems will be covered in detail, highlighting advances in this rapidly developing field. Students’ grades will be based on participation in discussion of current research and review articles, as well as exams.
